HDAC10

Histone deacetylase 10 (HDAC10) is an enzyme that in humans is encoded by the HDAC10 gene. This enzyme is part of the histone deacetylase family, which plays a critical role in the regulation of gene expression by modifying the chromatin structure.

Function

HDAC10 is involved in the removal of acetyl groups from lysine residues on histone proteins, leading to chromatin condensation and transcriptional repression. This process is essential for the regulation of gene expression and is implicated in various cellular processes, including cell cycle progression, differentiation, and apoptosis.

Clinical significance

Alterations in HDAC10 expression have been associated with several cancers, including neuroblastoma and colorectal cancer. Inhibitors targeting HDAC10 are being explored as potential therapeutic agents in cancer treatment due to their ability to induce cell cycle arrest and apoptosis in cancer cells.

Structure

HDAC10 is characterized by a unique structure that includes a catalytic domain similar to other class IIb histone deacetylases. It also contains a second domain that is thought to be involved in substrate recognition and binding.

Interactions

HDAC10 interacts with various proteins and transcription factors, influencing their activity and stability. These interactions are crucial for its role in regulating gene expression and maintaining cellular homeostasis.

Research

Ongoing research is focused on understanding the specific substrates and biological pathways regulated by HDAC10. This knowledge could lead to the development of more selective HDAC10 inhibitors with improved therapeutic profiles.

See also

• Histone deacetylase
• Gene expression
• Chromatin
• Cancer therapy

External links

• HDAC10 gene - NCBI
• HDAC10 protein - UniProt