Dornase alfa
Dornase alfa
Dornase alfa (pronounced: dor-NAYZ AL-fuh) is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Dornase alfa is produced by recombinant DNA technology in an Ovarian cell line of Chinese hamsters.
Etymology
The name "Dornase alfa" is derived from the type of enzyme it is (a DNAse), and "alfa" signifies that it is the first of its kind to be used therapeutically.
Usage
Dornase alfa is used to manage symptoms of cystic fibrosis, a genetic disorder that affects the lungs and digestive system. It works by breaking down excess DNA in the pulmonary secretions of people with cystic fibrosis, which reduces the thickness and stickiness of the mucus in the lungs, making it easier to breathe.
Related Terms
- Recombinant DNA: DNA that has been formed artificially by combining constituents from different organisms.
- Cystic fibrosis: A hereditary disorder affecting the exocrine glands, causing the production of abnormally thick mucus, leading to the blockage of the pancreatic ducts, intestines, and bronchi, often resulting in respiratory infection.
- DNA: Deoxyribonucleic acid, a self-replicating material present in nearly all living organisms as the main constituent of chromosomes. It is the carrier of genetic information.
- Enzyme: A substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.
External links
- Medical encyclopedia article on Dornase alfa
- Wikipedia's article - Dornase alfa
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