Normethadone

Normethadone

Normethadone (/nɔːrˈmɛθədoʊn/), also known as Phenadoxone, is a synthetic opioid analgesic similar to methadone. It is used for the treatment of moderate to severe pain, and in some countries, it is used as a part of opioid substitution therapy for patients with opioid use disorder.

Etymology

The term "Normethadone" is derived from the words "normal" and "methadone". The prefix "nor-" is a common term in organic chemistry, indicating that the compound is a demethylated derivative of another compound, in this case, methadone.

Pharmacology

Normethadone is a full agonist at the mu-opioid receptor, the main therapeutic target for most opioids. It also has some activity at the kappa-opioid receptor and the delta-opioid receptor. Like other opioids, normethadone can cause physical dependence and withdrawal symptoms if discontinued abruptly.

Medical Uses

Normethadone is used for the treatment of moderate to severe pain. It is also used in some countries as a part of opioid substitution therapy for patients with opioid use disorder, similar to the use of methadone or buprenorphine.

Side Effects

Common side effects of normethadone include constipation, nausea, vomiting, dizziness, and sedation. Serious side effects may include respiratory depression and addiction.

Related Terms

• Opioid
• Methadone
• Buprenorphine
• Mu-opioid receptor
• Kappa-opioid receptor
• Delta-opioid receptor

External links

• Medical encyclopedia article on Normethadone
• Wikipedia's article - Normethadone

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