Ambroxol

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  Structural formula of Ambroxol

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  Ball-and-stick model of Ambroxol

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  Antbron 15mg by Towa Pharmaceutical

Ambroxol

Ambroxol is a mucolytic agent used in the treatment of respiratory diseases associated with viscous or excessive mucus. It is commonly used to alleviate symptoms of cough and chronic obstructive pulmonary disease (COPD).

Pharmacology

Ambroxol works by breaking down mucopolysaccharides in the mucus, thereby reducing its viscosity and facilitating its clearance from the respiratory tract. It enhances the production of surfactant, a substance that helps keep the alveoli open, improving lung function.

Mechanism of Action

Ambroxol acts on the serous cells of the respiratory tract to increase the production of thin, watery secretions. This action helps to dilute the mucus, making it less sticky and easier to expel through coughing. Additionally, ambroxol has been shown to have anti-inflammatory and antioxidant properties, which may contribute to its therapeutic effects.

Clinical Uses

Ambroxol is indicated for use in conditions where there is excessive or thickened mucus, such as:

• Chronic bronchitis
• Asthma
• Bronchiectasis
• Cystic fibrosis
• Pneumonia

It is also used as an adjunct therapy in the management of acute respiratory distress syndrome (ARDS).

Dosage and Administration

Ambroxol is available in various forms, including tablets, syrups, and inhalation solutions. The dosage and administration depend on the age of the patient and the severity of the condition. It is important to follow the prescribed dosage to avoid potential side effects.

Side Effects

Common side effects of ambroxol include:

• Gastrointestinal disturbances such as nausea and vomiting
• Allergic reactions like rash and urticaria
• Headache

Severe side effects are rare but may include anaphylactic reactions and Stevens-Johnson syndrome.

Contraindications

Ambroxol is contraindicated in patients with known hypersensitivity to the drug or any of its components. Caution is advised in patients with peptic ulcer disease and those with a history of gastrointestinal bleeding.

Related Pages

• Mucolytic agent
• Chronic obstructive pulmonary disease
• Cough
• Respiratory tract

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