Letosteine
Letosteine is a mucolytic agent used in the treatment of respiratory diseases associated with excessive mucus production. It is a derivative of the amino acid cysteine, and it works by breaking down the structure of mucus in the lungs to make it easier to cough up.
Mechanism of Action
Letosteine works by disrupting the disulfide bonds in the glycoproteins that make up mucus, reducing its viscosity and elasticity. This makes the mucus less sticky and easier to cough up, helping to clear the airways and improve breathing.
Uses
Letosteine is used in the treatment of a variety of respiratory conditions where excessive mucus production is a problem. These include chronic bronchitis, asthma, and cystic fibrosis. It can also be used to help manage symptoms in conditions such as COPD (Chronic Obstructive Pulmonary Disease) and bronchiectasis.
Side Effects
As with all medications, Letosteine can cause side effects, although not everyone will experience them. Common side effects can include nausea, vomiting, abdominal pain, and diarrhea. If these or any other side effects occur, it is important to seek medical advice.
Contraindications
Letosteine should not be used by people with a known allergy to the medication. It should also be used with caution in people with a history of peptic ulcer disease, as it can potentially irritate the stomach lining.
Interactions
Letosteine can potentially interact with other medications, including those used to thin the blood, such as warfarin. It is important to inform your healthcare provider of all medications you are currently taking before starting treatment with Letosteine.
See Also
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Contributors: Prab R. Tumpati, MD