Dimethyl fumarate
Dimethyl fumarate
Dimethyl fumarate (pronunciation: dye-METH-il foo-MAR-ate) is a medication used in the treatment of multiple sclerosis and psoriasis. It is also known by its brand names Tecfidera and Skilarence.
Etymology
The term "Dimethyl fumarate" is derived from its chemical structure. "Dimethyl" refers to the presence of two methyl groups in the molecule, while "fumarate" is derived from fumaric acid, a compound it closely resembles.
Usage
Dimethyl fumarate is used in the treatment of relapsing forms of multiple sclerosis (MS). It is also used to treat moderate to severe plaque psoriasis in adults who have not responded to other systemic therapies.
Mechanism of Action
Dimethyl fumarate works by decreasing inflammation and preventing the immune system's harmful effects on myelin, the protective coating around nerve fibers in the brain and spinal cord. This helps to slow the progression of disability in people with multiple sclerosis.
Side Effects
Common side effects of dimethyl fumarate include flushing, stomach pain, diarrhea, and nausea. Serious side effects can include allergic reactions, PML (a rare brain infection), and decreases in white blood cell count.
Related Terms
External links
- Medical encyclopedia article on Dimethyl fumarate
- Wikipedia's article - Dimethyl fumarate
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