Krebs cycle
Krebs Cycle
The Krebs Cycle (pronounced: /krɛbz/), also known as the Citric Acid Cycle or the Tricarboxylic Acid Cycle (TCA cycle), is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetate derived from carbohydrates, fats, and proteins into carbon dioxide and chemical energy in the form of adenosine triphosphate (ATP).
Etymology
The Krebs Cycle is named after Hans Adolf Krebs, a German-British biochemist who first identified the series of reactions in 1937. The term "cycle" refers to the fact that the process begins with a molecule that is regenerated at the end of the cycle.
Process
The Krebs Cycle begins with the condensation of acetyl-CoA and oxaloacetate to form citrate. This is followed by a series of reactions that release carbon dioxide, transfer electrons to NAD+ and FAD, and generate ATP. The cycle ends with the regeneration of oxaloacetate, ready to start another round of the cycle.
Related Terms
- Glycolysis: The process that precedes the Krebs Cycle in the breakdown of glucose to produce ATP.
- Oxidative Phosphorylation: The process that follows the Krebs Cycle, using the electrons generated to produce more ATP.
- Mitochondria: The organelle in which the Krebs Cycle takes place.
- Pyruvate: The product of glycolysis that is converted into acetyl-CoA to enter the Krebs Cycle.
External links
- Medical encyclopedia article on Krebs cycle
- Wikipedia's article - Krebs cycle
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