Xanthoma: Difference between revisions
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{{Infobox medical condition | |||
[[File:Xanthoma.jpg|thumb| | | name = Xanthoma | ||
| image = [[File:Xanthoma.jpg|left|thumb|Xanthoma on the skin]] | |||
| caption = Xanthoma on the skin | |||
| field = [[Dermatology]] | |||
| synonyms = Xanthomatosis | |||
| symptoms = Yellowish deposits of fat underneath the skin | |||
| complications = [[Atherosclerosis]], [[coronary artery disease]] | |||
| onset = Varies, often in adulthood | |||
| duration = Chronic | |||
| causes = [[Hyperlipidemia]], [[diabetes mellitus]], [[primary biliary cholangitis]] | |||
| risks = High cholesterol, genetic factors | |||
| diagnosis = [[Physical examination]], [[biopsy]], [[blood test]] | |||
| differential = [[Lipoma]], [[sebaceous cyst]], [[neurofibroma]] | |||
| treatment = [[Lipid-lowering medication]], [[dietary changes]], [[surgery]] | |||
| prognosis = Depends on underlying cause | |||
| frequency = Common in individuals with lipid metabolism disorders | |||
}} | |||
Xanthomas are non-cancerous (benign) skin lesions caused by the accumulation of fat in macrophage immune cells within the skin and other tissues. These growths may vary in size and can appear anywhere on the body, but are most frequently seen on the elbows, joints, tendons, knees, hands, feet, and buttocks. They can serve as indicators of underlying lipid metabolism disorders or other conditions leading to elevated levels of blood lipids. | Xanthomas are non-cancerous (benign) skin lesions caused by the accumulation of fat in macrophage immune cells within the skin and other tissues. These growths may vary in size and can appear anywhere on the body, but are most frequently seen on the elbows, joints, tendons, knees, hands, feet, and buttocks. They can serve as indicators of underlying lipid metabolism disorders or other conditions leading to elevated levels of blood lipids. | ||
== Causes == | == Causes == | ||
Xanthelasma palpebra is a common type of xanthoma that appears on the eyelids or under the skin. Many things can cause Xanthomas in addition to elevated | Xanthelasma palpebra is a common type of xanthoma that appears on the eyelids or under the skin. Many things can cause Xanthomas in addition to elevated | ||
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== Appearance == | == Appearance == | ||
A xanthoma looks like a yellow to orange papule with defined borders. There may be several individual ones or they may form clusters. | A xanthoma looks like a yellow to orange papule with defined borders. There may be several individual ones or they may form clusters. | ||
== Symptoms and signs == | == Symptoms and signs == | ||
The xanthomas cause unsightly bumps and can cause itching, irritation and or ulceration. | The xanthomas cause unsightly bumps and can cause itching, irritation and or ulceration. | ||
[[File:Xanthoma 100X.jpg|alt=Xanthoma histology|thumb|Xanthoma histology]] | [[File:Xanthoma 100X.jpg|alt=Xanthoma histology|left|thumb|Xanthoma histology]] | ||
== Investigations == | == Investigations == | ||
Lipid profile, liver function, and metabolic panel, including blood sugar test for diabetes. | Lipid profile, liver function, and metabolic panel, including blood sugar test for diabetes. | ||
== Treatment == | == Treatment == | ||
If you have a disease that causes increased blood lipids, treating the condition may help reduce the development of xanthomas. | If you have a disease that causes increased blood lipids, treating the condition may help reduce the development of xanthomas. | ||
If the growth bothers you, your provider may remove it by surgery or with a laser. However, xanthomas may come back after surgery. | If the growth bothers you, your provider may remove it by surgery or with a laser. However, xanthomas may come back after surgery. | ||
== Prognosis == | == Prognosis == | ||
The growth is noncancerous and painless, but may be a sign of another medical condition. | The growth is noncancerous and painless, but may be a sign of another medical condition. | ||
== Prevention == | == Prevention == | ||
Treating the underlying cause such as elevated blood cholesterol or other causes. | Treating the underlying cause such as elevated blood cholesterol or other causes. | ||
== See Also == | == See Also == | ||
* [[Hyperlipidemia]] | * [[Hyperlipidemia]] | ||
* [[Atherosclerosis]] | * [[Atherosclerosis]] | ||
* [[Dermatology]] | * [[Dermatology]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
* Davis, M.D., & Johnson, M. (2015). ''Xanthomas: Diagnostic and Therapeutic Implications''. Journal of Dermatological Science. | * Davis, M.D., & Johnson, M. (2015). ''Xanthomas: Diagnostic and Therapeutic Implications''. Journal of Dermatological Science. | ||
* Robinson, J. (2018). ''Lipid Disorders and Skin: Xanthomas and More''. Dermatology Clinics. | * Robinson, J. (2018). ''Lipid Disorders and Skin: Xanthomas and More''. Dermatology Clinics. | ||
[[Category: Medical Conditions]] | [[Category: Medical Conditions]] | ||
[[Category: Skin Lesions]] | [[Category: Skin Lesions]] | ||
[[Category: Dermatology]] | [[Category: Dermatology]] | ||
{{Diseases of the skin and appendages by morphology}} | {{Diseases of the skin and appendages by morphology}} | ||
{{Lipidemias}} | {{Lipidemias}} | ||
Latest revision as of 20:32, 8 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Xanthoma | |
|---|---|
 | |
| Synonyms | Xanthomatosis |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Yellowish deposits of fat underneath the skin |
| Complications | Atherosclerosis, coronary artery disease |
| Onset | Varies, often in adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Hyperlipidemia, diabetes mellitus, primary biliary cholangitis |
| Risks | High cholesterol, genetic factors |
| Diagnosis | Physical examination, biopsy, blood test |
| Differential diagnosis | Lipoma, sebaceous cyst, neurofibroma |
| Prevention | N/A |
| Treatment | Lipid-lowering medication, dietary changes, surgery |
| Medication | N/A |
| Prognosis | Depends on underlying cause |
| Frequency | Common in individuals with lipid metabolism disorders |
| Deaths | N/A |
Xanthomas are non-cancerous (benign) skin lesions caused by the accumulation of fat in macrophage immune cells within the skin and other tissues. These growths may vary in size and can appear anywhere on the body, but are most frequently seen on the elbows, joints, tendons, knees, hands, feet, and buttocks. They can serve as indicators of underlying lipid metabolism disorders or other conditions leading to elevated levels of blood lipids.
Causes[edit]
Xanthelasma palpebra is a common type of xanthoma that appears on the eyelids or under the skin. Many things can cause Xanthomas in addition to elevated
Appearance[edit]
A xanthoma looks like a yellow to orange papule with defined borders. There may be several individual ones or they may form clusters.
Symptoms and signs[edit]
The xanthomas cause unsightly bumps and can cause itching, irritation and or ulceration.
Investigations[edit]
Lipid profile, liver function, and metabolic panel, including blood sugar test for diabetes.
Treatment[edit]
If you have a disease that causes increased blood lipids, treating the condition may help reduce the development of xanthomas. If the growth bothers you, your provider may remove it by surgery or with a laser. However, xanthomas may come back after surgery.
Prognosis[edit]
The growth is noncancerous and painless, but may be a sign of another medical condition.
Prevention[edit]
Treating the underlying cause such as elevated blood cholesterol or other causes.
See Also[edit]
References[edit]
<references/>
- Davis, M.D., & Johnson, M. (2015). Xanthomas: Diagnostic and Therapeutic Implications. Journal of Dermatological Science.
- Robinson, J. (2018). Lipid Disorders and Skin: Xanthomas and More. Dermatology Clinics.
| Diseases of the skin and appendages by morphology | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Inborn error of lipid metabolism: dyslipidemia (E78, 272.0–272.6) | ||||||||
|---|---|---|---|---|---|---|---|---|
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