Hypoalphalipoproteinemia

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Hypoalphalipoproteinemia
Synonyms	Low HDL cholesterol
Pronounce
Specialty	Endocrinology
Symptoms	Low levels of high-density lipoprotein (HDL) cholesterol
Complications	Increased risk of cardiovascular disease
Onset
Duration
Types
Causes	Genetic mutations, lifestyle factors
Risks	Family history, poor diet, lack of exercise
Diagnosis	Blood test measuring HDL levels
Differential diagnosis	Tangier disease, Familial hypercholesterolemia
Prevention	Healthy lifestyle, regular exercise
Treatment	Lifestyle changes, medications
Medication	Statins, Niacin
Prognosis	Variable, depending on management
Frequency	Rare
Deaths	N/A

Hypoalphalipoproteinemia is a medical condition characterized by decreased levels of high-density lipoprotein (HDL) in the blood. HDL is often referred to as "good cholesterol" because it carries cholesterol from other parts of your body back to your liver, which removes the cholesterol from your body.

Causes

Hypoalphalipoproteinemia can be caused by a variety of factors, including genetics, lifestyle choices, and certain medical conditions. Genetic causes include mutations in genes such as APOA1, APOC3, and LCAT. Lifestyle factors that can contribute to hypoalphalipoproteinemia include smoking, lack of exercise, and a diet high in saturated fat and cholesterol. Medical conditions that can cause hypoalphalipoproteinemia include type 2 diabetes, obesity, and metabolic syndrome.

Symptoms

Hypoalphalipoproteinemia itself does not cause symptoms. However, because HDL plays a crucial role in removing cholesterol from the body, individuals with hypoalphalipoproteinemia are at an increased risk of developing atherosclerosis and coronary artery disease. These conditions can lead to symptoms such as chest pain, shortness of breath, and fatigue.

Diagnosis

Hypoalphalipoproteinemia is typically diagnosed through a blood test that measures the levels of different types of cholesterol in the blood. If the levels of HDL are found to be below the normal range, a diagnosis of hypoalphalipoproteinemia may be made.

Treatment

Treatment for hypoalphalipoproteinemia typically involves lifestyle changes such as quitting smoking, increasing physical activity, and adopting a diet low in saturated fat and cholesterol. In some cases, medication may be prescribed to increase HDL levels.

See also

• Hyperlipidemia
• Dyslipidemia
• Lipoprotein metabolism

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