Insulin aspart
Insulin aspart
Insulin aspart (pronounced as IN-su-lin AS-part) is a type of insulin, a hormone that regulates the amount of glucose in the blood. It is a fast-acting insulin analog marketed by Novo Nordisk as a component in NovoLog/NovoRapid.
Etymology
The term "insulin" comes from the Latin insula, meaning "island", referring to the insulin-producing islets of Langerhans in the pancreas. "Aspart" refers to the substitution of the amino acid proline with aspartic acid at position B28 in the insulin structure, which gives insulin aspart its fast-acting properties.
Usage
Insulin aspart is used to treat people with diabetes mellitus who require insulin to control their blood sugar levels. It is typically used in combination with a longer-acting insulin for full-day coverage.
Pharmacology
Insulin aspart is a recombinant, biosynthetic, fast-acting insulin analog. It has a single amino acid substitution at position B28 where proline is replaced with aspartic acid. This alteration allows the insulin aspart molecule to be absorbed quickly into the bloodstream, leading to faster onset and shorter duration of action compared to regular human insulin.
Related Terms
- Insulin
- Diabetes mellitus
- Novo Nordisk
- Islets of Langerhans
- Blood sugar
- Amino acid
- Proline
- Aspartic acid
External links
- Medical encyclopedia article on Insulin aspart
- Wikipedia's article - Insulin aspart
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