Pramlintide
Pramlintide
Pramlintide (pronounced pram-LIN-tide) is a synthetic analogue of the human hormone amylin. It is used as an adjunct treatment in patients with diabetes who use insulin and have failed to achieve desired glucose control despite optimal insulin therapy.
Etymology
The name "Pramlintide" is derived from the words "prandial" (relating to a meal) and "amylin" (the hormone it mimics). The "tide" suffix is common in names of peptides, indicating its chemical structure.
Usage
Pramlintide is used in conjunction with insulin to lower blood sugar levels in adults with type 1 or type 2 diabetes. It is administered via subcutaneous injection and works by slowing gastric emptying, suppressing postprandial glucagon secretion, and regulating food intake through centrally mediated appetite suppression.
Side Effects
Common side effects of Pramlintide include nausea, vomiting, abdominal pain, and headache. Severe hypoglycemia can occur when Pramlintide is used in combination with insulin.
Related Terms
- Amylin: A hormone that is co-secreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1 (insulin:amylin).
- Insulin: A hormone that regulates the amount of glucose in the blood.
- Diabetes: A group of metabolic disorders characterized by a high blood sugar level over a prolonged period.
- Hypoglycemia: A condition characterized by an abnormally low level of blood sugar (glucose), your body's main energy source.
External links
- Medical encyclopedia article on Pramlintide
- Wikipedia's article - Pramlintide
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