Epalrestat
Epalrestat
Epalrestat (/ɛpɑːlrɛstæt/) is an aldose reductase inhibitor which is predominantly used for the management and treatment of diabetic neuropathy.
Etymology
The term "Epalrestat" is derived from its chemical name, which is 5-((1Z,2E)-2-methyl-3-phenylprop-2-en-1-ylidene)-4-oxo-2-thioxo-1,3-thiazolidine-3-acetic acid.
Usage
Epalrestat is used to alleviate symptoms associated with diabetic neuropathy, a condition that affects the nerves in patients with diabetes. It works by inhibiting the enzyme aldose reductase, which is involved in the conversion of glucose to sorbitol. This process is believed to contribute to the nerve damage seen in diabetic neuropathy.
Related Terms
- Aldose reductase inhibitor: A class of drugs that prevent damage to the nerves, kidneys, and retina by inhibiting the enzyme aldose reductase.
- Diabetic neuropathy: A type of nerve damage that can occur with diabetes.
- Diabetes: A disease that occurs when your blood glucose, also called blood sugar, is too high.
Side Effects
Common side effects of Epalrestat include liver dysfunction, gastrointestinal disturbances, and skin rash. It is advised to monitor liver function regularly while taking this medication.
Precautions
Epalrestat should be used with caution in patients with liver disease and in those who are pregnant or breastfeeding. It is also important to monitor blood glucose levels regularly while taking this medication.
External links
- Medical encyclopedia article on Epalrestat
- Wikipedia's article - Epalrestat
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