Tolrestat
Tolrestat
Tolrestat (pronounced: /toʊlˈrɛstæt/) is a non-enzymatic aldose reductase inhibitor that was primarily used in the management of diabetic complications. It was withdrawn from the market due to severe hepatotoxicity.
Etymology
The term "Tolrestat" is derived from the chemical name tolyl resorcinol state, indicating its chemical structure and function.
Usage
Tolrestat was used to manage and prevent the progression of long-term complications in patients with diabetes mellitus, such as diabetic neuropathy. It works by inhibiting the enzyme aldose reductase, which is involved in the conversion of glucose to sorbitol. Accumulation of sorbitol in cells can lead to various diabetic complications.
Side Effects
The use of Tolrestat was associated with several side effects, including liver damage, jaundice, and hepatitis. Due to these severe side effects, Tolrestat was withdrawn from the market.
Related Terms
- Aldose reductase inhibitor
- Diabetic complications
- Hepatotoxicity
- Diabetes mellitus
- Diabetic neuropathy
- Liver damage
- Jaundice
- Hepatitis
External links
- Medical encyclopedia article on Tolrestat
- Wikipedia's article - Tolrestat
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