Osteosclerotic plasma cell myeloma

Cancer of plasma cells

Not to be confused with Malignant melanoma.

Multiple myeloma
Synonyms	N/A
Pronounce	N/A
Field	Hematology and oncology
Symptoms	Bone pain, fatigue<ref name=":5" />
Complications	Amyloidosis, kidney problems, bone fractures, hyperviscosity syndrome, infections, anemia<ref name="NIH2016Pro" /><ref name=":5" />
Onset
Duration	Long term<ref name="NIH2016Pro" />
Types	N/A
Causes	Unknown<ref name="WCR2014Cp513" />
Risks	Obesity<ref name="WCR2014Cp2" />
Diagnosis	Blood or urine tests, bone marrow biopsy, medical imaging<ref name="Raab2009" />
Differential diagnosis
Prevention
Treatment	Steroids, chemotherapy, thalidomide, stem cell transplant, bisphosphonates, radiation therapy<ref name="NIH2016Pro" /><ref name="Raab2009" />
Medication
Prognosis	Five-year survival rate 54% / life expectancy 6 years (USA)<ref name="SEER2016" />
Frequency	488,200 (affected during 2015)<ref name="GBD2015Pre" />
Deaths	101,100 (2015)<ref name="GBD2015De" />

A plasma cell neoplasm associated with osteosclerotic and fibrotic changes in the bone trabeculae.

Lymph node changes

Often, the lymph nodes show changes resembling the plasma cell variant of castleman disease.

POEMS syndrome

It is often part of poems syndrome which is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes.

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