MKL1
MKL1 (also known as Megakaryoblastic Leukemia 1) is a protein that in humans is encoded by the MKL1 gene. It is a member of the myocardin family of transcription coactivators.
Function[edit]
MKL1 is a transcriptional coactivator that interacts with serum response factor (SRF) to modulate gene expression. It is involved in the regulation of muscle development and function. MKL1 has been implicated in chromosomal translocation events in patients with acute megakaryoblastic leukemia.
Clinical significance[edit]
Mutations in the MKL1 gene have been associated with acute megakaryoblastic leukemia. The MKL1 gene is also involved in a chromosomal translocation with the RBM15 gene in cases of acute megakaryoblastic leukemia.
See also[edit]
References[edit]
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External links[edit]
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