Monoclonal gammopathy of undetermined significance
Monoclonal gammopathy of undetermined significance (pronunciation: mɒnəˈkləʊn(ə)l ɡæməˈpæθi ɒv ʌndɪˈtɜːmɪnd sɪɡˈnɪfɪkəns), often abbreviated as MGUS, is a condition characterized by the presence of an abnormal protein in the blood, known as a monoclonal protein or M protein.
Etymology
The term "monoclonal gammopathy" refers to the production of a single type of gamma globulin (a type of protein) by a single clone of cells. The term "undetermined significance" indicates that the clinical implications of this condition are not fully understood.
Overview
MGUS is usually discovered incidentally during routine blood tests. It is considered a premalignant condition, as it may progress to multiple myeloma or other serious diseases. However, most individuals with MGUS remain asymptomatic and do not require treatment.
Symptoms
MGUS itself does not usually cause symptoms. However, if it progresses to a more serious condition, symptoms such as fatigue, bone pain, and weight loss may occur.
Diagnosis
Diagnosis of MGUS involves detecting the presence of M protein in the blood using a test called serum protein electrophoresis (SPEP). Further tests may be needed to rule out other conditions.
Treatment
As MGUS does not typically cause symptoms or complications, treatment is usually not necessary. However, regular monitoring is recommended to detect any progression to more serious conditions.
Related Terms
See Also
External links
- Medical encyclopedia article on Monoclonal gammopathy of undetermined significance
- Wikipedia's article - Monoclonal gammopathy of undetermined significance
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