Necrobiotic xanthogranuloma
Necrobiotic Xanthogranuloma (nek-roh-bi-ot-ik zan-tho-gran-u-lo-ma) is a rare and chronic granulomatous disorder that primarily affects the skin and is associated with paraproteinemia. It was first described in 1980 by Kossard and Winkelmann.
Etymology
The term "Necrobiotic Xanthogranuloma" is derived from three Greek words: "nekros" meaning dead, "bios" meaning life, "xanthos" meaning yellow, and "granuloma" which is a medical term for a type of inflammation.
Symptoms
The most common symptom of Necrobiotic Xanthogranuloma is the presence of yellowish or reddish-brown nodules or plaques on the skin, particularly around the eyes. These lesions may be accompanied by pruritus (itching) and can lead to disfigurement and functional impairment.
Diagnosis
Diagnosis of Necrobiotic Xanthogranuloma is typically made through a combination of clinical examination, histopathology of skin lesions, and the detection of paraproteinemia.
Treatment
Treatment options for Necrobiotic Xanthogranuloma are limited due to the rarity of the condition. Current treatments include systemic corticosteroids, chemotherapy, and radiotherapy.
Prognosis
The prognosis for Necrobiotic Xanthogranuloma varies widely, with some patients experiencing a slow progression of the disease over many years, while others may experience a more aggressive course.
See Also
- Granuloma
- Paraproteinemia
- Nodules
- Plaques
- Pruritus
- Histopathology
- Corticosteroids
- Chemotherapy
- Radiotherapy
External links
- Medical encyclopedia article on Necrobiotic xanthogranuloma
- Wikipedia's article - Necrobiotic xanthogranuloma
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