Drug-induced keratoderma

Drug-induced keratoderma
Synonyms
Pronounce	N/A
Specialty	Dermatology
Symptoms	Thickening of the skin on the palms and soles
Complications
Onset
Duration
Types	N/A
Causes	Drug reaction
Risks
Diagnosis	Clinical diagnosis
Differential diagnosis	Palmoplantar keratoderma, Psoriasis, Eczema
Prevention	Avoidance of causative drugs
Treatment	Discontinuation of the offending drug, topical treatments
Medication	Keratolytics, Emollients
Prognosis	Generally good with drug discontinuation
Frequency	Rare
Deaths	N/A

Drug-induced keratoderma is a condition characterized by the thickening of the skin on the palms of the hands and the soles of the feet. This condition is caused by the use of certain medications.

Causes

Drug-induced keratoderma is caused by the use of certain medications. These medications include retinoids, cytotoxic drugs, and antiretroviral drugs. The exact mechanism by which these drugs cause keratoderma is not fully understood.

Symptoms

The main symptom of drug-induced keratoderma is the thickening of the skin on the palms of the hands and the soles of the feet. This thickening can be accompanied by other symptoms such as redness, itching, and pain.

Diagnosis

The diagnosis of drug-induced keratoderma is made based on the patient's medical history, physical examination, and the results of skin biopsy. The skin biopsy can show characteristic changes in the skin that are indicative of keratoderma.

Treatment

The treatment of drug-induced keratoderma involves discontinuing the offending medication and treating the symptoms. Topical treatments such as emollients and keratolytics can be used to soften the skin and reduce the thickness of the skin. In severe cases, systemic treatments such as retinoids may be used.

See also

• Keratoderma
• Drug-induced conditions
• Skin conditions