Lymphoproliferative disorders

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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Lymphoproliferative disorders
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Lymphadenopathy, fever, night sweats, weight loss
Complications	Infection, anemia, organ failure
Onset	Variable, often in adulthood
Duration	Chronic
Types	Non-Hodgkin lymphoma, Hodgkin lymphoma, Chronic lymphocytic leukemia, Multiple myeloma
Causes	Genetic mutations, viral infections (e.g., Epstein-Barr virus)
Risks	Immunosuppression, autoimmune diseases, family history
Diagnosis	Blood tests, bone marrow biopsy, imaging studies
Differential diagnosis	N/A
Prevention	N/A
Treatment	Chemotherapy, radiation therapy, immunotherapy, stem cell transplant
Medication	N/A
Prognosis	Variable, depends on type and stage
Frequency	Common
Deaths	N/A

Lymphoproliferative disorders are diseases characterized by the abnormal proliferation of lymphocytes, a type of white blood cell. These disorders can be benign or malignant and can affect both children and adults. They are often associated with immune system dysfunction.

Types of Lymphoproliferative Disorders

There are several types of lymphoproliferative disorders, including:

• Chronic lymphocytic leukemia (CLL)
• Non-Hodgkin lymphoma (NHL)
• Hodgkin lymphoma (HL)
• Multiple myeloma (MM)
• Waldenström macroglobulinemia (WM)

Causes

The exact cause of lymphoproliferative disorders is unknown, but they are often associated with immune system dysfunction. Some disorders are linked to specific genetic mutations, while others may be triggered by infections or exposure to certain chemicals or radiation.

Symptoms

Symptoms of lymphoproliferative disorders can vary widely depending on the specific disorder and the individual patient. Common symptoms may include:

• Fatigue
• Fever
• Night sweats
• Weight loss
• Swollen lymph nodes

Diagnosis

Diagnosis of lymphoproliferative disorders typically involves a combination of physical examination, medical history, laboratory tests, and imaging studies. A biopsy of affected tissue may also be performed.

Treatment

Treatment for lymphoproliferative disorders depends on the specific disorder and the patient's overall health. Options may include chemotherapy, radiation therapy, immunotherapy, targeted therapy, stem cell transplant, or a combination of these.

See Also

• Leukemia
• Lymphoma
• Myeloma
• Waldenström macroglobulinemia

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