Montelukast

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Montelukast
Montelukast 3D ball-and-stick

Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma. It is marketed as Singulair.

Information about Montelukast

Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma.

Liver safety of Montelukast

It has been linked to rare cases of clinically apparent liver injury.

Mechanism of action of Montelukast

Montelukast (mon" te loo' kast) is a leukotriene receptor antagonist that binds to the CysLT1 and CysLT2 receptors, thereby interfering with inflammatory pathways that are involved in the pathogenesis of asthma and allergic rhinitis. Montelukast has been shown to reduce symptoms of asthma and allergic rhinitis and prevent acute attacks.

FDA approval information for Montelukast

Montelukast was approved for use in the United States in 1998 and is widely used with more than 20 million prescriptions being filled yearly. Current indications for montelukast include prophylaxis and chronic treatment of asthma, prevention of exercise induced bronchoconstriction and allergic rhinitis.

Dosage and administration for Montelukast

Montelukast is available in several generic forms and under the commercial name Singulair. The recommended dosage for adults is 10 mg once daily. Lower doses and chewable tablets are recommended for pediatric patients.

Side effects of Montelukast

Common side effects include dyspepsia, abdominal discomfort, asthenia, headache, dizziness, fatigue and fever.

Drugs for obstructive airway diseases: asthma/COPD (R03)
Adrenergics, inhalants
Glucocorticoids
Anticholinergics/
muscarinic antagonist
Mast cell stabilizers
Xanthines



Leukotriene signaling modulators
Receptor
(ligands)
BLT
CysLT
Enzyme
(inhibitors)
Others


Merck & Co., Inc.
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Contributors: Prab R. Tumpati, MD