Telotristat

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Telotristat (pronounced te-lo-TRI-stat) is a medication used in the treatment of carcinoid syndrome not adequately controlled by somatostatin analogue therapy. The term "Telotristat" is derived from the Greek words "telos" meaning "end" and "tristis" meaning "sad", reflecting its use in treating a serious condition.

Usage

Telotristat is used in combination with somatostatin analogue therapy to treat adults with carcinoid syndrome diarrhea that has not been adequately controlled by the analogue therapy alone. It works by reducing the production of serotonin in the body, which in turn reduces the frequency of diarrhea and flushing.

Dosage

The recommended dosage of Telotristat is 250 mg taken orally three times daily with food. If patients experience certain side effects or have not achieved adequate symptom control after 2 weeks on this dosage, the dosage may be increased to 500 mg three times daily.

Side Effects

Common side effects of Telotristat include nausea, headache, elevated liver enzymes, depression, peripheral edema, flatulence, decreased appetite, and fever. Serious side effects may include constipation and gastrointestinal obstruction.

Contraindications

Telotristat is contraindicated in patients with known hypersensitivity to Telotristat or any of its components. It should be used with caution in patients with a history of biliary tract obstruction, gallbladder stones, or chronic constipation.

Interactions

Telotristat may interact with certain other medications, including cytochrome P450 3A4 (CYP3A4) substrates, serotonergic drugs, and oral contraceptives. Patients should inform their healthcare provider of all medications they are currently taking before starting treatment with Telotristat.

See Also

External links

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