SKF-91488
SKF-91488 is a drug used in scientific research, which acts as a selective antagonist for the D1 dopamine receptor.[1] It has been used in the study of Parkinson's disease and other medical conditions where dopamine function is impaired.
Pharmacology
SKF-91488 is a selective antagonist for the D1 dopamine receptor. This means it binds to this receptor and blocks its activation by dopamine. This can be useful in research to understand the role of the D1 receptor in various physiological processes and diseases.
Uses in Research
SKF-91488 has been used in research to study the role of the D1 receptor in various conditions. For example, it has been used in studies of Parkinson's disease, a condition characterized by the death of dopamine-producing cells in the brain. By blocking the D1 receptor, researchers can study the effects of reduced dopamine activity on the symptoms of this disease.
Side Effects
As with any drug, SKF-91488 can have side effects. These can include nausea, vomiting, and other gastrointestinal symptoms. However, because it is used primarily in research rather than in clinical practice, these side effects are typically managed in a controlled laboratory setting.
See Also
References
- ↑ , SKF 91488, a selective D1 dopamine receptor antagonist, European Journal of Pharmacology, Vol. 86(Issue: 3–4), pp. 241–50, DOI: 10.1016/0014-2999(84)90368-3, PMID: 6326961,
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Contributors: Prab R. Tumpati, MD
