Reticular pigmented anomaly of the flexures
Reticular Pigmented Anomaly of the Flexures
Reticular Pigmented Anomaly of the Flexures (pronunciation: reh-tick-yoo-lar pig-men-ted an-om-a-ly of the flex-yours), also known as Dowling-Degos disease, is a rare, genetic skin disorder characterized by reticulate hyperpigmentation of the flexures.
Etymology
The term "reticular" is derived from the Latin word "reticulum", meaning "net", and refers to the net-like pattern of pigmentation seen in this condition. The term "pigmented" refers to the increased melanin in the affected areas, and "anomaly" refers to the abnormal development. The term "flexures" refers to the areas of the body where the skin folds, such as the armpits, groin, and neck.
Symptoms
The primary symptom of Reticular Pigmented Anomaly of the Flexures is the presence of dark, net-like hyperpigmentation in the flexural areas of the body. These areas include the armpits, groin, neck, and under the breasts. The pigmentation is usually symmetrical and progressive. Other symptoms may include comedones, pitted scars, and acneiform eruptions.
Causes
Reticular Pigmented Anomaly of the Flexures is a genetic disorder caused by mutations in the KRT5 gene. This gene provides instructions for making a protein that is essential for the normal development of the skin.
Diagnosis
Diagnosis of Reticular Pigmented Anomaly of the Flexures is primarily based on the characteristic clinical features. A skin biopsy may be performed to confirm the diagnosis. Genetic testing may also be done to identify mutations in the KRT5 gene.
Treatment
There is currently no cure for Reticular Pigmented Anomaly of the Flexures. Treatment is aimed at managing the symptoms and may include the use of topical retinoids, laser therapy, and dermabrasion.
Related Terms
External links
- Medical encyclopedia article on Reticular pigmented anomaly of the flexures
- Wikipedia's article - Reticular pigmented anomaly of the flexures
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