Ichthyosis hystrix
Ichthyosis Hystrix
Ichthyosis hystrix (pronounced ik-thee-OH-sis HIS-triks) is a rare type of ichthyosis, a group of genetic skin disorders characterized by dry, thickened, scaly skin.
Etymology
The term "ichthyosis" is derived from the Greek word "ichthys," meaning fish, due to the scaly appearance of the skin. "Hystrix" is Latin for porcupine, referring to the spiky, rough texture of the skin in this condition.
Symptoms
Ichthyosis hystrix is characterized by widespread, spiny, darkly pigmented hyperkeratosis, which is an overgrowth of the outermost layer of the skin. Other symptoms may include erythroderma, or redness and inflammation of the skin, and alopecia, or hair loss.
Causes
Ichthyosis hystrix is caused by mutations in the KRT1 or KRT10 genes, which provide instructions for making proteins that form the structure of skin cells. These mutations disrupt the normal development of skin cells, leading to the characteristic features of ichthyosis hystrix.
Treatment
Treatment for ichthyosis hystrix primarily involves managing symptoms and improving the condition of the skin. This may include the use of moisturizers, keratolytic agents (which help to remove excess skin), and retinoids (medications that promote the turnover of skin cells).
Related Terms
- Ichthyosis: A group of genetic skin disorders characterized by dry, thickened, scaly skin.
- Hyperkeratosis: An overgrowth of the outermost layer of the skin.
- Erythroderma: Redness and inflammation of the skin.
- Alopecia: Hair loss.
- KRT1: A gene that provides instructions for making a protein that forms the structure of skin cells.
- KRT10: A gene that provides instructions for making a protein that forms the structure of skin cells.
External links
- Medical encyclopedia article on Ichthyosis hystrix
- Wikipedia's article - Ichthyosis hystrix
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