Acantholysis
Acantholysis
Acantholysis (pronounced: a-kan-tho-ly-sis) is a medical term that refers to the loss of intercellular connections, such as desmosomes, resulting in the loss of cohesion between keratinocytes, the predominant cell type in the skin's outermost layer. This condition is often seen in skin diseases such as Pemphigus vulgaris and Darier's disease.
Etymology
The term 'Acantholysis' is derived from the Greek words 'akantha' meaning thorn or spine and 'lysis' meaning loosening or dissolving. It essentially refers to the 'loosening' or 'dissolving' of the 'spines' or 'thorns' that hold the skin cells together.
Related Terms
- Keratinocyte: The predominant cell type in the skin's outermost layer, which is affected in acantholysis.
- Desmosome: A type of intercellular junction that connects keratinocytes and is lost in acantholysis.
- Pemphigus vulgaris: A rare autoimmune disease that causes acantholysis.
- Darier's disease: A genetic disorder characterized by acantholysis.
See Also
External links
- Medical encyclopedia article on Acantholysis
- Wikipedia's article - Acantholysis
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