Keratin 18

Keratin 18 (also known as KRT18) is a type of keratin protein that is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. It is encoded by the KRT18 gene in humans.

Structure

Keratin 18, along with its filament partner Keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis.

Function

Keratin 18 provides mechanical support for the cells, and in partnership with keratin 8, helps to protect hepatocytes from apoptosis. It also plays a significant role in the process of cellular specialization.

Clinical significance

Mutations in the KRT18 gene can lead to a variety of pathologies. For example, a mutation can cause cirrhosis of the liver. Additionally, the KRT18 gene and its protein product are involved in several types of cancer, including hepatocellular carcinoma and pancreatic cancer.

See also

• Keratin
• Keratin 8
• Cirrhosis
• Hepatocellular carcinoma
• Pancreatic cancer

References

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