Siramesine
Siramesine
Siramesine (pronunciation: si-rah-meh-seen) is a sigma receptor agonist that was originally developed as an anxiolytic drug by the pharmaceutical company H. Lundbeck A/S. It has been studied for its potential use in the treatment of various medical conditions, including cancer, obesity, and neurodegenerative diseases.
Etymology
The term "Siramesine" is derived from the Greek word "sira", meaning "thread", and "mesine", a term of unknown origin. The name was likely chosen to reflect the drug's ability to "thread" or interact with sigma receptors in the body.
Pharmacology
Siramesine acts as an agonist at the sigma-1 receptor and sigma-2 receptor, proteins that are found in the brain and other tissues. By binding to these receptors, Siramesine can influence various biological processes, including cell growth and survival, neurotransmission, and immune response.
Clinical Trials
Several clinical trials have been conducted to evaluate the safety and efficacy of Siramesine in treating various conditions. For example, a phase II trial was conducted to assess the drug's potential as a treatment for anxiety disorders. However, the drug did not show significant benefits over placebo and development was discontinued.
More recently, preclinical studies have suggested that Siramesine may have potential as a treatment for cancer. The drug has been shown to induce cell death in various types of cancer cells, including breast cancer cells and glioblastoma cells. However, these findings are preliminary and further research is needed to confirm the drug's potential in this area.
Related Terms
- Sigma receptor: A type of protein found in the brain and other tissues that Siramesine binds to.
- Anxiolytic: A type of medication used to reduce anxiety.
- H. Lundbeck A/S: The pharmaceutical company that originally developed Siramesine.
- Cancer: A group of diseases characterized by the uncontrolled growth and spread of abnormal cells.
- Obesity: A medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.
- Neurodegenerative diseases: A group of disorders characterized by the progressive loss of structure or function of neurons, including death of neurons.
External links
- Medical encyclopedia article on Siramesine
- Wikipedia's article - Siramesine
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