Calcitonin gene-related peptide

Calcitonin gene-related peptide (pronunciation: /kælˌsɪtoʊˈniːn dʒiːn rɪˈleɪtɪd ˈpɛptʌɪd/), often abbreviated as CGRP, is a member of the calcitonin family of peptides. It is a potent vasodilator and can function in the transmission of pain. In the nervous system, CGRP is found in the C cells of the thyroid and in neurons in the central and peripheral nervous system.

Etymology

The term "calcitonin" is derived from the Latin calx or calcis meaning "lime" due to its ability to quickly lower blood calcium levels. The "gene-related peptide" part of the name refers to the peptide's production through alternative splicing of the calcitonin gene.

Function

CGRP plays a key role in the cardiovascular system, the digestive system, and the immune system. It is involved in the regulation of temperature, feeding, and sexual behavior. In the cardiovascular system, CGRP acts as a potent vasodilator and can help protect the heart during ischemia or myocardial infarction. In the digestive system, CGRP helps to regulate secretion and absorption. In the immune system, CGRP has been found to play a role in the body's response to stress and inflammation.

Clinical significance

CGRP is a target for novel therapeutic developments in various conditions, including migraine and cluster headache. CGRP receptor antagonists, such as erenumab, have been developed for the preventive treatment of migraines.

Related terms

• Calcitonin
• Vasodilation
• C cell
• Myocardial infarction
• Erenumab

External links

• Medical encyclopedia article on Calcitonin gene-related peptide
• Wikipedia's article - Calcitonin gene-related peptide

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