NE-100

NE-100 is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki = 1.03 ± 0.01 nM, and more than 205 times selectivity over the sigma-2 receptor. It has been used in scientific research.

Pharmacology

NE-100 is a selective sigma-1 receptor antagonist. The sigma-1 receptor is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. In the context of neurobiology, sigma-1 receptor agonists have been shown to promote neuroplasticity, while antagonists have been shown to block this activity.

Chemistry

NE-100 is a synthetic compound of the sigma receptor antagonist class. It is structurally related to other sigma receptor antagonists such as BD-1008 and BD-1047, but is reported to have greater selectivity for the sigma-1 subtype.

Research

NE-100 has been used in scientific research to study the role of sigma-1 receptors in various processes including neuroplasticity, pain perception, and the action of certain drugs of abuse. It has also been used to investigate the potential therapeutic applications of sigma-1 receptor antagonists in conditions such as depression, anxiety, and schizophrenia.

See also

• Sigma-1 receptor
• Sigma-2 receptor
• Sigma receptor antagonist
• BD-1008
• BD-1047

References

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