EA-2054

Ethacrynic Acid

Skeletal molecular structure of Ethacrynic Acid

Ethacrynic acid is a loop diuretic used in the management of edema associated with congestive heart failure, liver cirrhosis, and renal disease. Unlike other loop diuretics, ethacrynic acid does not contain a sulfonamide group, making it a suitable alternative for patients with sulfonamide allergies.

Pharmacology

Ethacrynic acid works by inhibiting the sodium-potassium-chloride symporter in the thick ascending limb of the loop of Henle in the nephron. This inhibition leads to a decrease in the reabsorption of sodium chloride, resulting in increased excretion of sodium, chloride, and water.

Mechanism of Action

The primary action of ethacrynic acid is to block the Na-K-2Cl symporter, which is responsible for the reabsorption of sodium, potassium, and chloride ions. By inhibiting this transporter, ethacrynic acid increases the osmolarity of the urine, leading to diuresis.

Pharmacokinetics

Ethacrynic acid is rapidly absorbed from the gastrointestinal tract and is extensively bound to plasma proteins. It is metabolized in the liver and excreted primarily in the urine.

Clinical Uses

Ethacrynic acid is primarily used to treat conditions associated with fluid overload, such as:

• Congestive heart failure
• Cirrhosis of the liver
• Nephrotic syndrome
• Pulmonary edema

Side Effects

Common side effects of ethacrynic acid include:

• Electrolyte imbalance
• Hypokalemia
• Hyponatremia
• Ototoxicity

Contraindications

Ethacrynic acid is contraindicated in patients with:

• Severe electrolyte depletion
• Anuria
• Hypersensitivity to ethacrynic acid

Related Pages

• Loop diuretic
• Diuretic
• Congestive heart failure
• Renal disease