Cyclopenthiazide

Cyclopenthiazide is a thiazide diuretic pharmaceutical drug used in the treatment of hypertension and edema. It is a member of the benzothiadiazine (a type of thiazide) class of drugs. It is primarily used in the management of hypertension and edema often due to congestive heart failure or renal insufficiency.

Pharmacology

Cyclopenthiazide works by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the nephron. This reduces the reabsorption of sodium and chloride ions, leading to an increased excretion of water in the urine, a process known as diuresis.

Side Effects

Like other thiazide diuretics, cyclopenthiazide can cause a range of side effects. These may include hypokalemia (low potassium levels), hyponatremia (low sodium levels), and hypercalcemia (high calcium levels). Other potential side effects include gout, hyperglycemia (high blood sugar), and an increased risk of cholesterol and triglyceride levels.

Interactions

Cyclopenthiazide can interact with a number of other medications. These include lithium, which can lead to increased lithium levels and potential lithium toxicity. It can also interact with nonsteroidal anti-inflammatory drugs (NSAIDs), which can reduce the diuretic effect of cyclopenthiazide.

See Also

• Thiazide
• Diuretic
• Hypertension
• Edema

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