Loop diuretic

Loop Diuretic

Loop diuretics (pronounced: lo͞op dyo͝oˈretik) are a type of diuretic that work by inhibiting the sodium-potassium-chloride (Na-K-Cl) symporter in the thick ascending limb of the loop of Henle in the kidneys, hence the name "loop" diuretic. This action prevents the reabsorption of sodium and chloride ions, leading to an increase in the volume of urine produced by the kidneys.

Etymology

The term "loop diuretic" is derived from the location of their action in the kidneys. The "loop" refers to the loop of Henle, a part of the nephron in the kidneys where these drugs exert their effect. The term "diuretic" comes from the Greek words "dia" meaning "through" and "ourein" meaning "to urinate".

Types of Loop Diuretics

There are several types of loop diuretics, including:

• Furosemide (Lasix)
• Bumetanide (Bumex)
• Torsemide (Demadex)
• Ethacrynic acid (Edecrin)

Each of these drugs has a slightly different mechanism of action, but all work by inhibiting the Na-K-Cl symporter in the loop of Henle.

Related Terms

• Diuretic: A substance that promotes diuresis, the increased production of urine.
• Nephron: The functional unit of the kidney.
• Loop of Henle: A part of the nephron in the kidney.
• Sodium-potassium-chloride symporter: A protein that aids in the reabsorption of sodium, potassium, and chloride ions in the kidney.

See Also

• Thiazide diuretics
• Potassium-sparing diuretics
• Osmotic diuretics

External links

• Medical encyclopedia article on Loop diuretic
• Wikipedia's article - Loop diuretic

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