Thiazolidinediones
Thiazolidinediones
Thiazolidinediones (pronounced: thy-uh-zoh-lih-deen-dye-ohns), also known as glitazones, are a class of medications used in the treatment of Type 2 diabetes. They are part of the antidiabetic drugs category and work by reducing insulin resistance in the body.
Etymology
The term "Thiazolidinediones" is derived from the chemical structure of these drugs, which includes a thiazolidine ring and two ketone groups. The suffix "-dione" is used in organic chemistry to denote the presence of two ketone groups.
Usage
Thiazolidinediones are used primarily in the treatment of Type 2 diabetes, a condition characterized by high blood sugar levels due to the body's inability to properly use insulin. They work by binding to the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ, in fat cells. This action makes the cells more responsive to insulin, thereby reducing blood sugar levels.
Related Terms
- Rosiglitazone: A type of thiazolidinedione medication.
- Pioglitazone: Another type of thiazolidinedione medication.
- Insulin resistance: A condition that thiazolidinediones help to treat.
- Type 2 diabetes: The primary condition for which thiazolidinediones are prescribed.
- Peroxisome proliferator-activated receptors: The receptors to which thiazolidinediones bind in order to exert their effect.
Side Effects
Like all medications, thiazolidinediones can cause side effects. These may include weight gain, anemia, and increased risk of heart failure. It is important to discuss these potential risks with a healthcare provider before starting treatment with a thiazolidinedione.
External links
- Medical encyclopedia article on Thiazolidinediones
- Wikipedia's article - Thiazolidinediones
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