Pulsatile insulin

From WikiMD's medical encyclopedia

Pulsatile Insulin is a method of insulin delivery that mimics the body's natural insulin release pattern. This method is also known as Pulsatile Insulin Therapy or PIT. It is used in the treatment of diabetes, a chronic condition characterized by high levels of glucose in the blood due to the body's inability to produce or use insulin effectively.

Overview

Pulsatile Insulin Therapy involves the intermittent administration of insulin in a pulsatile manner, rather than a continuous one. This is done to mimic the natural insulin secretion pattern of the pancreas. The therapy is believed to improve glucose control and reduce the risk of complications associated with diabetes.

Mechanism of Action

In Pulsatile Insulin Therapy, insulin is delivered in pulses, which are timed to coincide with the body's natural insulin release pattern. This is believed to enhance the body's sensitivity to insulin, thereby improving glucose control.

Benefits

Pulsatile Insulin Therapy has been shown to improve glucose control in people with diabetes. It may also reduce the risk of complications associated with diabetes, such as heart disease, kidney disease, and nerve damage.

Risks and Side Effects

As with any form of insulin therapy, Pulsatile Insulin Therapy carries some risks and potential side effects. These may include hypoglycemia (low blood sugar), weight gain, and skin reactions at the injection site.

See Also

References


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Contributors: Prab R. Tumpati, MD