MODY 2
MODY 2
MODY 2 or Maturity-Onset Diabetes of the Young, Type 2 is a form of diabetes that is often diagnosed in adolescence or early adulthood. Pronounced as "M-O-D-Y 2", the term originates from the words 'Maturity-Onset Diabetes of the Young', indicating its onset at a young age.
Definition
MODY 2 is a monogenic form of diabetes due to mutations in the GCK gene. It is characterized by mild, stable, fasting hyperglycemia and impaired glucose tolerance. Unlike other forms of diabetes, MODY 2 is typically not insulin-dependent.
Symptoms
The symptoms of MODY 2 are similar to those of other forms of diabetes, including frequent urination, excessive thirst, fatigue, and blurred vision. However, many people with MODY 2 do not experience symptoms and the condition is often diagnosed during routine blood tests.
Causes
MODY 2 is caused by mutations in the GCK gene. This gene provides instructions for making an enzyme called glucokinase, which plays a key role in regulating blood sugar levels. Mutations in the GCK gene disrupt the function of glucokinase, leading to the characteristic features of MODY 2.
Treatment
The treatment for MODY 2 typically involves lifestyle changes such as a healthy diet and regular exercise. Some people with MODY 2 may also require medication to control their blood sugar levels.
See Also
References
- National Library of Medicine. (n.d.). GCK gene. Genetics Home Reference. Retrieved from https://ghr.nlm.nih.gov/gene/GCK
- National Institute of Diabetes and Digestive and Kidney Diseases. (n.d.). Monogenic Diabetes (Neonatal Diabetes Mellitus & MODY). Retrieved from https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/monogenic-neonatal-mellitus-mody
External links
- Medical encyclopedia article on MODY 2
- Wikipedia's article - MODY 2
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