Peroxisome proliferator-activated receptor gamma

Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone receptor, is a type of nuclear receptor that is of interest for its role in biology and medicine. PPARG regulates fatty acid storage and glucose metabolism. The genes activated by PPARG stimulate lipid uptake and adipogenesis by fat cells.

Function

PPARG binds peroxisome proliferators and controls the size and number of peroxisomes produced within cells. PPARG is a regulator of adipocyte differentiation, and it also has anti-inflammatory effects and inhibits the vasoconstriction of vascular smooth muscle cells.

Clinical significance

PPARG has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis, and cancer. PPARG agonists have been used in the treatment of hyperlipidaemia and hyperglycemia.

Ligands

Several different kinds of ligands can bind to PPARG, including synthetic ligands, naturally occurring fatty acids, and prostaglandins.

See also

• Peroxisome proliferator-activated receptor
• Thiazolidinedione
• Fatty acid
• Adipogenesis
• Peroxisome

External links

• PPARG at the US National Library of Medicine Medical Subject Headings (MeSH)

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