Dose response
Dose Response
Dose response (pronunciation: /doʊs rɪˈspɒns/) is a fundamental concept in pharmacology and toxicology, referring to the relationship between the quantity of a drug or toxin and the effect it has on a living organism.
Etymology
The term "dose response" is derived from the English words "dose", which refers to a quantity of a medicine or drug taken or recommended to be taken at a particular time, and "response", which refers to a reaction to a stimulus.
Definition
In pharmacology, a dose response relationship is the relationship between the dose of the drug and the biological or behavioral effect of the drug. This relationship can be graphically represented by a dose response curve, which plots the magnitude of effect against the dose of the drug.
In toxicology, the dose response relationship describes the change in effect on an organism caused by differing levels of exposure (or doses) to a stressor (usually a chemical) after a certain exposure time.
Related Terms
- Pharmacodynamics: The study of the biochemical and physiological effects of drugs and their mechanisms of action.
- Pharmacokinetics: The study of how an organism affects a drug, including absorption, distribution, metabolism, and excretion.
- Toxicity: The degree to which a substance can damage an organism.
- Therapeutic index: The ratio of the dose of a drug that causes a lethal or toxic effect to the dose that causes a therapeutic effect.
See Also
External links
- Medical encyclopedia article on Dose response
- Wikipedia's article - Dose response
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