Adverse drug reaction

Adverse drug reaction
Synonyms	ADR, drug side effect
Pronounce	N/A
Specialty	N/A
Symptoms	Rash, nausea, vomiting, diarrhea, headache, dizziness, anaphylaxis
Complications	Anaphylactic shock, organ failure, death
Onset	Varies depending on the drug and individual
Duration	Varies; can be temporary or permanent
Types	N/A
Causes	Medication use
Risks	Polypharmacy, allergies, genetic predisposition
Diagnosis	Clinical history, physical examination, laboratory tests
Differential diagnosis	Drug allergy, drug intolerance, drug interaction
Prevention	Medication review, patient education, pharmacogenomics
Treatment	Discontinuation of the drug, antihistamines, corticosteroids, supportive care
Medication	N/A
Prognosis	Varies; can be mild to life-threatening
Frequency	Common; varies by drug and population
Deaths	N/A

* An adverse drug reaction (ADR) refers to an unintended and harmful response to a medication. 

• It occurs when a drug, prescribed or taken as instructed, produces an undesirable or unexpected effect on the body.
• Adverse drug reactions can range from mild side effects to severe and life-threatening conditions.
• Understanding ADRs is crucial for healthcare professionals, patients, and regulatory bodies to ensure the safe and effective use of medications.

Drug eruption1

Classification of Adverse Drug Reactions

• Adverse drug reactions can be classified into several categories based on different criteria.

• The most common classification system divides ADRs into the following types:

Type A (Augmented)

• Type A reactions are the most common type of adverse drug reactions and are predictable based on a drug's known pharmacological properties.
• These reactions are dose-dependent and usually related to the drug's therapeutic effect or its interaction with specific receptors or enzymes.
• Type A reactions are typically mild to moderate and include side effects such as nausea, dizziness, and headache.

Type B (Bizarre)

• Type B reactions are unpredictable and unrelated to the known pharmacological action of a drug.
• They occur infrequently and are often severe or life-threatening.
• Type B reactions are typically not dose-dependent and can vary between individuals.
• Examples of type B reactions include severe allergic reactions (anaphylaxis), drug-induced liver injury, and blood dyscrasias.

Type C (Chronic)

• Type C reactions are associated with the long-term use of a drug.
• They arise from the cumulative effects of a medication over time.
• Examples of type C reactions include drug-induced osteoporosis, tardive dyskinesia caused by long-term use of antipsychotics, and drug-induced endocrine disorders.

Type D (Delayed)

• Type D reactions occur after a significant delay following drug administration.
• These reactions can manifest weeks, months, or even years after initiating treatment.
• Examples of type D reactions include certain drug-induced cancers, such as bladder cancer associated with long-term use of certain diabetes medications.

Type E (End-of-treatment)

• Type E reactions occur when a drug is abruptly stopped or withdrawn.
• They are often related to a rebound effect or withdrawal syndrome.
• Examples include rebound hypertension after discontinuing antihypertensive medications or seizures following abrupt withdrawal of antiepileptic drugs.

Risk Factors for Adverse Drug Reactions

• Several factors can contribute to the occurrence of adverse drug reactions.

These include:

• Age: Elderly individuals and children may be more susceptible to ADRs due to differences in drug metabolism, organ function, and physiological characteristics.
• Polypharmacy: Taking multiple medications simultaneously increases the risk of drug interactions and adverse effects.
• Genetic Factors: Genetic variations can influence how an individual responds to certain drugs, potentially increasing the likelihood of ADRs.
• Pre-existing Conditions: Certain medical conditions, such as liver or kidney impairment, can affect drug metabolism and increase the risk of ADRs.
• Drug Allergies: Individuals with known drug allergies or hypersensitivity reactions may experience severe ADRs upon exposure to the specific medication.
• Concomitant Diseases: Coexisting medical conditions can interact with drugs and increase the risk of adverse effects.

Prevention and Management

• Prevention and management of adverse drug reactions involve various strategies:

• Proper Medication Selection: Healthcare professionals should carefully consider a patient's medical history, allergies, and potential drug interactions before prescribing medications.
• Patient Education: Patients should be educated about the potential side effects and risks associated with their medications. They should be encouraged to report any unusual symptoms to their healthcare provider.
• Monitoring and Surveillance: Regular monitoring of patients receiving medications can help detect and manage ADRs promptly.
• Pharmacovigilance: Pharmacovigilance programs and regulatory systems play a crucial role in monitoring and reporting ADRs at a population level. This helps identify potential safety concerns and take appropriate regulatory actions if needed.
• Adherence to Guidelines: Healthcare professionals should follow evidence-based guidelines for prescribing medications and adjust dosage or therapy based on individual patient characteristics.
• Reporting and Documentation: ADRs should be reported to the relevant regulatory authorities or pharmacovigilance programs to contribute to the overall understanding of drug safety profiles.

See Also

• Pharmacovigilance
• Medication Safety
• Drug Interactions
• Anaphylaxis
• Polypharmacy

• Dailymed label info on Adverse drug reaction
• FDA Adverse drug reaction