O-581

O-581
[[File:|frameless|220px|alt=|Chemical structure of O-224]]
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Routes of administration	Oral
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Legal status	Research chemical
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O-224 is a synthetic cannabinoid compound that has been studied for its potential effects on the endocannabinoid system. It is a derivative of the well-known cannabinoid THC (tetrahydrocannabinol), which is the primary psychoactive component of cannabis. O-224 is primarily used in research settings to explore the pharmacological properties of cannabinoids and their potential therapeutic applications.

Chemical Structure and Properties

O-224 is a chemical analog of THC, with modifications to its molecular structure that alter its binding affinity and activity at cannabinoid receptors. The precise chemical structure of O-224 includes modifications that enhance its selectivity and potency at the CB1 receptor, a key component of the endocannabinoid system.

Pharmacology

O-224 acts as a potent agonist at the CB1 receptor, which is predominantly found in the central nervous system. This receptor is responsible for mediating many of the psychoactive effects of cannabinoids. The binding of O-224 to the CB1 receptor results in the activation of intracellular signaling pathways that can influence various physiological processes, including pain perception, mood regulation, and appetite control.

Research and Applications

Research on O-224 has focused on its potential therapeutic applications, particularly in the areas of pain management, neurological disorders, and psychiatric conditions. Studies have shown that O-224 may have analgesic properties, making it a candidate for the development of new pain relief medications. Additionally, its effects on mood and cognition are being explored for potential use in treating conditions such as anxiety and depression.

Safety and Legal Status

As a research chemical, O-224 is not approved for medical use in humans. Its safety profile is not well-established, and it is typically used in controlled laboratory settings. The legal status of O-224 varies by jurisdiction, and it is important for researchers to comply with local regulations when conducting studies involving this compound.

Also see

• Cannabinoid receptor
• Endocannabinoid system
• Synthetic cannabinoids
• Tetrahydrocannabinol (THC)
• Cannabis research