JWH-057

JWH-057 ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Identifiers ;
PubChem	44417060 ;
ChemSpider	23271524 ; ;
ChEMBL	370726
Chemical data ;
Chemical formula	C25H25N1O1 ;
SMILES	CCCCCC1=CC2=C(C=C1)C(=CN2)C(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)C ; ;

Synthetic cannabinoid

JWH-057 is a synthetic cannabinoid from the naphthoylindole family. It was first synthesized by the chemist John W. Huffman and is used in scientific research. JWH-057 acts as a potent agonist at both the CB1 and CB2 cannabinoid receptors.

Chemical properties[edit]

JWH-057 has the IUPAC name (4-methyl-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-methanone. Its molecular formula is C25H25NO, and it has a molecular weight of 359.47 g/mol. The structure consists of a naphthalene ring substituted with a methyl group and a pentylindole moiety.

Pharmacology[edit]

JWH-057 is known to bind to the CB1 and CB2 receptors, which are part of the endocannabinoid system. These receptors are involved in various physiological processes including pain sensation, appetite, and mood. The binding affinity of JWH-057 to these receptors is similar to that of other synthetic cannabinoids, making it a subject of interest in the study of cannabinoid receptor interactions.

Legal status[edit]

The legal status of JWH-057 varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Researchers must often obtain special licenses to work with this compound.

References[edit]

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JWH-057
Identifiers
PubChem	44417060
ChemSpider	23271524
ChEMBL	370726
Chemical data
Chemical formula	C₂₅H₂₅N₁O₁
SMILES	`CCCCCC1=CC2=C(C=C1)C(=CN2)C(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)C`