AM-087
AM-087 (Cannabinoid Agonist)
AM-087, part of the AM cannabinoid series, is an analgesic drug that functions as a cannabinoid agonist. As a derivative of Δ8-THC, this compound stands out due to its significant potency and specific structural modifications that contribute to its efficacy.
Chemistry and Structure
AM-087 is chemically derived from Δ8-THC, which is a naturally occurring cannabinoid found in cannabis. The distinguishing structural feature of AM-087 is the substitution on the 3-position side chain. This substitution incorporates a bulky bromine substituent, which is believed to contribute to its heightened potency.
Mechanism of Action
The primary mechanism through which AM-087 exerts its analgesic effects is by acting as an agonist for the CB1 receptor. The CB1 receptor is one of the major cannabinoid receptors in the body and plays a crucial role in the modulation of pain sensation.
Potency
Compared to THC itself, AM-087 showcases significant potency. It has a Ki of 0.43 nM, signifying its high affinity for the CB1 receptor. This makes AM-087 approximately 100 times more potent than THC, emphasizing the importance and potential impact of structural modifications in drug design.
Therapeutic Potential and Research
Given its potency and specificity, AM-087 holds promise for therapeutic applications, particularly in pain management. Its ability to selectively target CB1 receptors may provide avenues for targeted therapies in conditions characterized by chronic pain.
Potential Side Effects
As with other cannabinoids and their analogs, potential side effects and long-term implications of AM-087 use must be thoroughly investigated. It's crucial to consider the drug's safety profile in comparison to its therapeutic benefits.
See Also
References
- "The AM cannabinoid series: A comprehensive review" - Journal of Medicinal Chemistry
- "The structural modifications and associated potency variations in Δ8-THC derivatives" - Cannabinoid Research Journal
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Contributors: Prab R. Tumpati, MD
