AM-11245

Synthetic cannabinoid

AM-11245
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
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Legal status
CAS Number	1345973-53-6
PubChem	57347112
DrugBank
ChemSpider	29763156
KEGG

AM-11245 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of a class of compounds known as indole-based cannabinoids, which are structurally distinct from the naturally occurring cannabinoids found in the Cannabis plant.

Chemical Structure

Chemical structure of AM-11245

AM-11245 is characterized by its indole core, which is substituted at the 3-position with a tetramethylcyclopropylmethanone group. The 1-position of the indole is substituted with a 5-fluoropentyl chain. This structure is similar to other synthetic cannabinoids, which often feature a core indole or indazole structure with various substituents that enhance their affinity for cannabinoid receptors.

Pharmacology

AM-11245 acts as a full agonist at the CB₁ and CB₂ receptors, which are part of the endocannabinoid system. This system is involved in regulating a variety of physiological processes including mood, appetite, and pain sensation. The potency and efficacy of AM-11245 at these receptors contribute to its psychoactive effects, which can mimic those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Legal Status

The legal status of AM-11245 varies by country. In many jurisdictions, synthetic cannabinoids are controlled substances due to their potential for abuse and lack of medical use. These compounds are often included in legislation targeting "designer drugs" or "novel psychoactive substances" (NPS).

Safety and Toxicity

The safety profile of AM-11245 is not well-documented, as is the case with many synthetic cannabinoids. These compounds can pose significant health risks, including cardiovascular and neurological effects. Users may experience adverse reactions such as tachycardia, hypertension, anxiety, and hallucinations.

Related Compounds

AM-11245 is part of a broader class of synthetic cannabinoids that includes other compounds such as JWH-018, AM-2201, and AB-FUBINACA. These compounds share similar mechanisms of action but differ in their chemical structures and potencies.

Related Pages

• Cannabinoid receptor
• Synthetic cannabinoids
• Endocannabinoid system
• Designer drug