Oleamide

From WikiMD's medical encyclopedia

Oleamide is a fatty acid primary amide that is derived from oleic acid. It is a naturally occurring molecule that is found in the bodies of animals and is also present in some plants. Oleamide has several functions in the body, including acting as a sleep-inducing agent, a neurotransmitter, and a molecular chaperone.

Structure and Synthesis

Oleamide is a long-chain fatty acid amide with the chemical formula C18H35NO. It is synthesized in the body from oleic acid and ammonia through the action of the enzyme fatty acid amide hydrolase (FAAH). The synthesis of oleamide can be increased in response to certain stimuli, such as physical stress or sleep deprivation.

Functions

Oleamide has several functions in the body. It is a potent sleep-inducing agent and is thought to be responsible for the sleep-inducing effects of certain foods, such as turkey and milk. Oleamide also acts as a neurotransmitter in the brain, where it is involved in the regulation of mood and memory. In addition, oleamide acts as a molecular chaperone, helping to fold proteins into their correct three-dimensional structures.

Medical Uses

Oleamide has potential medical uses in the treatment of a variety of conditions. It has been shown to have anti-inflammatory and analgesic effects, making it potentially useful in the treatment of conditions such as arthritis and chronic pain. Oleamide also has anxiolytic effects, suggesting that it could be used to treat anxiety disorders. In addition, oleamide has been shown to have antidepressant effects, making it a potential treatment for depression.

Side Effects

While oleamide is generally considered safe, it can have side effects in some people. These can include drowsiness, dizziness, and nausea. In rare cases, oleamide can cause allergic reactions, including rash, itching, and swelling.

See Also

References

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Oleamide

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Contributors: Prab R. Tumpati, MD