Indium (111In) capromab pendetide
| Indium (111In) capromab pendetide
| |
|---|---|
| CAS Number | 151763-64-3
|
| ChemSpider | none
|
Indium (111In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer.[1] Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA.[2] Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single photon emission computed tomography (SPECT).[1]
Early trials with yttrium (90Y) capromab pendetide were also conducted.[3]
References[edit]
- ↑ 1.0 1.1 "Indium-111 capromab pendetide in the management of recurrent prostate cancer".Expert Review of Anticancer Therapy.2008;8(2)
- 175–81.doi:10.1586/14737140.8.2.175.PMID:18279057.
- ↑ WHO Drug Information
- ↑ Kahn, Daniel."A Phase II Study of [90Y] Yttrium-Capromab Pendetide in the Treatment of Men with Prostate Cancer Recurrence Following Radical Prostatectomy".Cancer Biotherapy & Radiopharmaceuticals.1999;14(2)
- 99.doi:10.1089/cbr.1999.14.99.
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