ETS2

ETS2 (v-ets avian erythroblastosis virus E26 oncogene homolog 2) is a gene that encodes a protein which belongs to the ETS family of transcription factors. This protein plays a crucial role in various biological processes, including cell growth, differentiation, and apoptosis.

Function

The ETS2 gene is a member of the ETS family of transcription factors and is regulated by signaling pathways. These transcription factors are involved in a variety of biological processes, including cell growth, differentiation, apoptosis, and tissue remodeling. The ETS2 protein is a nuclear target for the ras-raf-MAPK signaling cascade.

Clinical significance

Alterations in the ETS2 gene are associated with several health conditions. For instance, an extra copy of the ETS2 gene is present in people with Down syndrome, which is thought to contribute to the characteristic features of this condition. Additionally, mutations in the ETS2 gene have been linked to various types of cancer, including leukemia and solid tumors.

Interactions

ETS2 has been shown to interact with:

• C-jun
• MAPK1
• PIN1
• RASA1
• STAT5A
• STAT5B

See also

• ETS transcription factor family
• Down syndrome
• Cancer

References

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External links

• ETS2 at the US National Library of Medicine Medical Subject Headings (MeSH)