Technetium (99mTc) nofetumomab merpentan

Technetium (99mTc) nofetumomab merpentan
File:Technetium-99m nofetumomab merpentan skeletal.svg
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life	10.5 hours
Excretion	renal (64%)
Legal status
CAS Number	165942-79-0
PubChem
DrugBank
ChemSpider	none
KEGG

Technetium (^99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,<ref>,

 Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer, 
 Clinical nuclear medicine, 
 2000,
 Vol. 25(Issue: 1),
 pp. 54–5,
 DOI: 10.1097/00003072-200001000-00013,
 PMID: 10634533,</ref> gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.<ref>, 
 Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy, 
 Clinical nuclear medicine, 
 1997,
 Vol. 22(Issue: 9),
 pp. 615–20,
 DOI: 10.1097/00003072-199709000-00007,
 PMID: 9298295,</ref> The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).<ref>WHO Drug Information</ref>

Nofetumomab

Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.<ref>Molecular Biology of B Cells. p533</ref> and/or CD20/MS4A1<ref>technetium (99mTc) nofetumomab merpentan (TAB-711) </ref>

It is the Fab part of murine MAb NR-LU-10.<ref name=MARTK/>

Merpentan

The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.<ref name=MARTK>Monoclonal Antibody Radionuclide Test Kits</ref>

Phenthioate

Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate<ref>Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters US 3934010 A</ref>

References

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• Technetium-99m nofetumomab merpentan skeletal structure
  Technetium-99m nofetumomab merpentan skeletal structure