Bivalirudin
Bivalirudin (pronounced bih-VAL-ih-roo-din) is a synthetic anticoagulant used to prevent blood clots in patients who have severe chest pain or who are undergoing a certain type of heart procedure (angioplasty).
Etymology
The term "Bivalirudin" is derived from its structure and function. The prefix "bi-" refers to its two-fold mechanism of action, "vali-" is derived from the Latin "validus" meaning strong, and "-rudin" is a common suffix for direct thrombin inhibitors.
Pharmacology
Bivalirudin directly inhibits thrombin, a protein in the blood that facilitates clotting. By inhibiting thrombin, Bivalirudin prevents the formation of blood clots. It is a specific and reversible direct thrombin inhibitor.
Usage
Bivalirudin is used in combination with aspirin to prevent blood clotting in patients undergoing angioplasty. It is also used in patients with or at risk of heparin induced thrombocytopenia and thrombosis syndrome (HIT/HITTS) undergoing percutaneous coronary intervention (PCI).
Side Effects
Common side effects of Bivalirudin include back pain, nausea, and headache. Serious side effects may include bleeding, allergic reactions, and slow heart rate.
Related Terms
- Anticoagulant
- Thrombin
- Angioplasty
- Aspirin
- Heparin
- Thrombocytopenia
- Percutaneous coronary intervention
External links
- Medical encyclopedia article on Bivalirudin
- Wikipedia's article - Bivalirudin
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