Factor IX
Factor IX
Factor IX (pronounced as "factor nine") is one of the serine proteases of the coagulation system, balancing the properties of blood clotting and anticoagulation. It plays a crucial role in the coagulation cascade, which is a complex process that leads to the formation of a clot to prevent excessive bleeding following an injury.
Etymology
The term "Factor IX" is derived from its position in the coagulation cascade. It was the ninth factor to be discovered in this cascade, hence the name.
Function
Factor IX is activated by Factor XIa in the intrinsic pathway and by Factor VII/tissue factor complex in the extrinsic pathway. The activated Factor IX (Factor IXa), in combination with Factor VIII, activates Factor X. This leads to the conversion of prothrombin to thrombin, which then converts fibrinogen to fibrin, resulting in clot formation.
Related Terms
- Hemophilia B: Also known as Christmas disease, it is a blood clotting disorder caused by a mutation of the Factor IX gene, leading to a deficiency of Factor IX.
- Coagulation: The process by which blood changes from a liquid to a gel, forming a clot.
- Prothrombin: A protein present in blood plasma that is converted into active thrombin during coagulation.
- Thrombin: An enzyme in blood plasma that causes the clotting of blood by converting fibrinogen to fibrin.
See Also
External links
- Medical encyclopedia article on Factor IX
- Wikipedia's article - Factor IX
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