Reconstitution

Reconstitution (/ˌriːkɒnstɪˈtjuːʃən/) refers to the process of returning a substance, especially a drug or vaccine, to its original state by adding a solvent. This is often done with medications that are stored in a powder form for long-term stability and must be reconstituted with a suitable solvent before administration.

Etymology

The term "reconstitution" is derived from the Latin re- meaning "again" and constituere meaning "to set up or establish". It was first used in the medical context in the late 19th century.

Related Terms

Solvent: A substance, typically a liquid, used to dissolve another substance.
Solution: A homogeneous mixture composed of two or more substances.
Suspension (chemistry): A heterogeneous mixture that contains solid particles sufficiently large for sedimentation.
Diluent: A substance that dilutes something, especially a drug or vaccine.
Lyophilization: Also known as freeze-drying, it is a process used to dehydrate a substance, often for the purpose of preservation or storage.

Process

Reconstitution typically involves adding a specified amount of solvent to the powdered drug or vaccine. The mixture is then shaken or stirred until the powder is completely dissolved, resulting in a solution or suspension that is ready for administration. The exact process can vary depending on the specific drug or vaccine and the solvent used.

Importance

Reconstitution is a critical step in the preparation of many drugs and vaccines. It allows these substances to be stored in a stable, concentrated form, reducing the risk of degradation and contamination. It also allows for precise dosing, as the amount of drug or vaccine can be accurately measured once it is in solution or suspension form.