Tioclomarol
| Tioclomarol | |
|---|---|
| Tioclomarol.svg | |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Tioclomarol is an anticoagulant medication that is used to prevent the formation of harmful blood clots in the blood vessels. It is a coumarin derivative, similar to other anticoagulants such as warfarin.
Mechanism of Action[edit]
Tioclomarol works by inhibiting the synthesis of vitamin K-dependent clotting factors in the liver. These clotting factors include factor II, factor VII, factor IX, and factor X. By reducing the levels of these factors, tioclomarol decreases the blood's ability to clot, thus preventing thrombosis.
Pharmacokinetics[edit]
Tioclomarol is administered orally and is absorbed through the gastrointestinal tract. It is metabolized in the liver and excreted primarily in the urine. The drug has a long half-life, which allows for once-daily dosing.
Clinical Use[edit]
Tioclomarol is used in the prevention and treatment of venous thromboembolism, including deep vein thrombosis and pulmonary embolism. It is also used in patients with atrial fibrillation to reduce the risk of stroke.
Side Effects[edit]
Common side effects of tioclomarol include bleeding, bruising, and gastrointestinal disturbances. Patients taking tioclomarol require regular monitoring of their International Normalized Ratio (INR) to ensure that their blood is not too thin.
Contraindications[edit]
Tioclomarol is contraindicated in patients with active bleeding, severe liver disease, or hypersensitivity to the drug. It should be used with caution in patients with a history of peptic ulcer disease or hypertension.
Interactions[edit]
Tioclomarol can interact with a variety of medications, including antibiotics, antifungals, and nonsteroidal anti-inflammatory drugs (NSAIDs). These interactions can increase the risk of bleeding or reduce the effectiveness of tioclomarol.
Related pages[edit]
-
Tioclomarol
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
