Tioclomarol

An anticoagulant medication

Tioclomarol
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Tioclomarol is an anticoagulant medication that is used to prevent the formation of harmful blood clots in the blood vessels. It is a coumarin derivative, similar to other anticoagulants such as warfarin.

Mechanism of Action

Tioclomarol works by inhibiting the synthesis of vitamin K-dependent clotting factors in the liver. These clotting factors include factor II, factor VII, factor IX, and factor X. By reducing the levels of these factors, tioclomarol decreases the blood's ability to clot, thus preventing thrombosis.

Pharmacokinetics

Tioclomarol is administered orally and is absorbed through the gastrointestinal tract. It is metabolized in the liver and excreted primarily in the urine. The drug has a long half-life, which allows for once-daily dosing.

Clinical Use

Tioclomarol is used in the prevention and treatment of venous thromboembolism, including deep vein thrombosis and pulmonary embolism. It is also used in patients with atrial fibrillation to reduce the risk of stroke.

Side Effects

Common side effects of tioclomarol include bleeding, bruising, and gastrointestinal disturbances. Patients taking tioclomarol require regular monitoring of their International Normalized Ratio (INR) to ensure that their blood is not too thin.

Contraindications

Tioclomarol is contraindicated in patients with active bleeding, severe liver disease, or hypersensitivity to the drug. It should be used with caution in patients with a history of peptic ulcer disease or hypertension.

Interactions

Tioclomarol can interact with a variety of medications, including antibiotics, antifungals, and nonsteroidal anti-inflammatory drugs (NSAIDs). These interactions can increase the risk of bleeding or reduce the effectiveness of tioclomarol.

Related pages

• Anticoagulant
• Warfarin
• Vitamin K
• Thrombosis

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  Tioclomarol